• Molecular mechanism of epigenetic aberrations on skin aging

    Funding: NSFC, SMUDH

    Collaborators: Zhengfeng, LIU

    The regeneration ability of epidermal stem cells (EpdSCs) gradually declines with age, eventually leading to the age-related decline of skin functions. The project aims to prioritize critical regulators in the gene regulatory network involved transcription factors (TFs), enhancers and ECM genes in EpdSCs with age through integrating multi-omics datasets.

  • Molecular mechanism of RBP-lncRNA interaction on subcellular localization

    Funding: NSFC

    Long noncoding RNA (lncRNA) plays a vital role in various biological processes. RNA binding protein (RBP) binds to lncRNAs and directs them to act their functions in a specific subcellular localization. However, the underlying mechanism needs further investigation. In this project, we intend to integrate multi-omics datasets and molecular techniques to study the mechanism of RBP-mediated lncRNA subcellular localization.

  • Molecular diagnosis using mass parallel sequencing technology

    Funding: SMUDH

    Collaborators: Prof. Yuhui Liao, Prof. Xiaoming Zhou, Dr. Bowen Shu

    This project aims to establish a massively parallel sequencing platform for pathogen diagnosis, including sample preparation, target pathogen enrichment, library preparation, nanopore sequencing, and algorithm/databases for pathogen identification.